A new study published in Chemical and Biological Technologies in Agriculture (2025) demonstrates a green extraction process using propylene glycol to recover valuable polyphenols from industrial hemp stems, an often-discarded agricultural byproduct.
By employing ultrasound-assisted extraction (UAE) and optimizing parameters through Box–Behnken design, the researchers achieved a high-yield extract (HUPG) rich in isofeuric acid, m-coumaric acid, and chelidonic acid. These compounds displayed potent antioxidant, antibacterial, and anti-inflammatory activities, inhibiting Staphylococcus aureus, E. coli, and P. aeruginosa while promoting wound healing in human keratinocytes.
Unlike traditional solvent extraction, the propylene glycol–based system is biocompatible, non-toxic, and consistent with green chemistry principles, reducing environmental impact while improving bioactive recovery. This approach highlights a promising path for valorizing hemp waste into high-value bioactive ingredients for cosmetic, nutraceutical, and pharmaceutical applications.
Reference
Myo, H., Khat-udomkiri, N., Sam-ang, P. et al. Propylene glycol-based green extraction of polyphenols from industrial hemp stems: process optimization and bioactivity assessment. Chem. Biol. Technol. Agric. 12, 149 (2025). https://doi.org/10.1186/s40538-025-00870-3
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