A research article published in Probiotics and Antimicrobial Proteins (2025) reports that Bacillus subtilis LN077 functions as an effective probiotic feed additive for improving goat growth and health. The study was conducted on twelve 3-month-old Yudong black goats divided into control and probiotic groups, with the latter receiving feed supplemented with 1 mL of B. subtilis LN077 per kilogram for 60 days.
Goats fed the probiotic displayed significantly higher final weights and average daily gains, along with increased serum antioxidant enzyme activities (T-SOD, GSH-Px, and T-AOC) and immunoglobulin G (IgG) levels. Inflammatory cytokines IL-6 and TNF-α were markedly reduced, reflecting enhanced immune regulation.
Metabolic analyses revealed that B. subtilis LN077 improved rumen fermentation efficiency—lowering ammonia-nitrogen (NH₃-N) while increasing acetate and total volatile fatty acids (TVFAs). High-throughput sequencing showed enrichment of beneficial microbial taxa such as Chloroflexi, Patescibacteria, Clostridia UCG-014, Candidatus Saccharimonas, Bifidobacteriaceae, and Ruminococcaceae, all linked to better fiber degradation and nutrient absorption.
Untargeted metabolomics identified 1,281 differentially expressed metabolites, mainly associated with arachidonic acid, glutathione, and phenylalanine metabolism. Several key metabolites—like spermidine, theophylline, and dihydroceramide—were positively correlated with immune and antioxidant functions.
The findings highlight that Bacillus subtilis LN077 not only promotes growth and immunity but also rebalances the rumen microbiome and metabolic pathways, offering a sustainable alternative to antibiotics in goat production systems.
Reference
Zhou, X., Xiang, W., & Shen, X. (2025). Bacillus Subtilis LN077 as a Probiotic Feed Additive Improves Goat Growth, Immunity, and Rumen Health. Probiotics and Antimicrobial Proteins. https://doi.org/10.1007/s12602-025-10809-7
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