Physicochemical characterization and immune activity of water-extract polysaccharides by stepwise ethanol precipitation from wild Cordyceps sinensis
Posted inAgriculture Biochemistry Biodiversity

Wild Cordyceps sinensis Polysaccharides Show Precision Immune-Boosting Potential Through MAPK/NF-κB Pathway

A new study reveals how polysaccharides from wild Cordyceps sinensis, separated via stepwise ethanol precipitation, enhance immune activity by activating macrophages through the MAPK/NF-κB pathway. These structure-dependent bioactive compounds offer promising potential for precision nutraceutical development.
Medicinal fungi-derived secondary metabolites as potential inhibitors of DNA polymerase beta: a computational approach against liver cancer.
Posted inEmerging Science Health Molecular Biology

Medicinal Mushrooms Show Promise in Liver Cancer Treatment Through DNA Repair Enzyme Inhibition

A computational study identifies medicinal mushroom compounds that inhibit DNA polymerase β—an enzyme linked to tumor progression in hepatocellular carcinoma. The lead compound, Phellibaumin A, exhibits strong binding affinity, favorable pharmacokinetics, and low toxicity, suggesting a potential new route for liver cancer therapy.