Medicinal fungi-derived secondary metabolites as potential inhibitors of DNA polymerase beta: a computational approach against liver cancer.
Posted inEmerging Science Health Molecular Biology

Medicinal Mushrooms Show Promise in Liver Cancer Treatment Through DNA Repair Enzyme Inhibition

A computational study identifies medicinal mushroom compounds that inhibit DNA polymerase β—an enzyme linked to tumor progression in hepatocellular carcinoma. The lead compound, Phellibaumin A, exhibits strong binding affinity, favorable pharmacokinetics, and low toxicity, suggesting a potential new route for liver cancer therapy.