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Genetic Engineering

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High-level production of Tauroursodeoxycholic acid from Taurochenodeoxycholic acid in engineered Bacillus subtilis via whole-cell biotransformation.
Posted inEmerging Science Genetic Engineering Health

Revolutionizing TUDCA Production: How Engineered Bacillus subtilis Unlocks a Cost-Effective Bear Bile Alternative

Discover how scientists engineered Bacillus subtilis to produce tauroursodeoxycholic acid (TUDCA) efficiently, offering a sustainable, ethical alternative to bear bile.
Posted by Aneknowledge September 30, 2025
Phage receptor binding protein and Fc fragment fusion enhances phagocytosis of Y. enterocolitica
Posted inBioinformatics Emerging Science Genetic Engineering

Phage-Protein Fusion Boosts Immune Defense Against Yersinia enterocolitica Infections

A new study shows that fusing phage receptor binding proteins with Fc fragments enhances immune cell recognition and phagocytosis of Yersinia enterocolitica, offering a novel antibacterial strategy.
Posted by Aneknowledge September 29, 2025
CluSeek: Bioinformatics Tool to Identify and Analyze Gene Clusters
Posted inBioinformatics Emerging Science Genetic Engineering

CluSeek: A New Tool for Efficient and Scalable Clustering of Large-Scale Genomic Data

CluSeek introduces a scalable and efficient approach to genomic data clustering, enabling faster insights into population genetics and precision medicine.
Posted by Aneknowledge September 28, 2025
From seed to whole plant: An innovative visual marker system to enhance selection efficiency in soybean genome editing
Posted inBioinformatics Emerging Science Genetic Engineering

A Visual Breakthrough: New Marker System Speeds Up Soybean Genome Editing

Scientists have developed a novel visual marker system (VSES4) that enables rapid, DNA-free identification of transgenic soybeans, streamlining CRISPR genome editing and boosting crop improvement.
Posted by Aneknowledge September 18, 2025
Comparative CRISPRi screens reveal a human stem cell dependence on mRNA translation-coupled quality control
Posted inEmerging Science Genetic Engineering Molecular Biology

CRISPRi Screens Reveal Stem Cells’ Unique Dependence on Translation Quality Control

A new study using comparative CRISPRi screens shows that human stem cells rely heavily on ribosome rescue and translation-coupled quality control, uncovering vulnerabilities with implications for development and disease.
Posted by Aneknowledge September 17, 2025
Scientists achieved DNA-free CRISPR genome editing in raspberry using ribonucleoprotein (RNP) transfection, paving the way for safer, non-GMO crop improvements.
Posted inEmerging Science Genetic Engineering Plant Biotechnology

CRISPR Breakthrough: DNA-Free Genome Editing in Raspberry Plants

Scientists achieved DNA-free CRISPR genome editing in raspberry using ribonucleoprotein (RNP) transfection, paving the way for safer, non-GMO crop improvements.
Posted by Aneknowledge September 14, 2025
A chimeric viral platform for directed evolution in mammalian cells
Posted inEmerging Science Genetic Engineering

Chimeric Viral Platform Revolutionizes Directed Evolution in Mammalian Cells

A new chimeric viral system enables continuous directed evolution in mammalian cells, accelerating the design of therapeutic proteins and viral vectors.
Posted by Aneknowledge September 12, 2025
Researchers create the maps to see which bits of the genome living organisms truly need to stay alive, and how badly they falter when any given bit goes missing.
Posted inBioinformatics Emerging Science Genetic Engineering

Quantitative Essentiality Mapping in Reduced Genomes: New Insights into Gene Function and Fitness

Explore how scientists created a high-resolution essentiality map in Mycoplasma pneumoniae, revealing the dynamic fitness roles of genes, regulatory elements, and protein domains. A breakthrough in synthetic biology and genome engineering.
Posted by Aneknowledge September 9, 2025
New Antibody-Based Approach Enables Safer Stem Cell Transplantation for Fanconi Anemia
Posted inEmerging Science Genetic Engineering Immunology

New Antibody-Based Approach Enables Safer Stem Cell Transplantation for Fanconi Anemia

A phase 1b trial shows that an anti-CD117 antibody (briquilimab) enables stem cell transplantation without toxic irradiation or busulfan in children with Fanconi anemia.
Posted by Aneknowledge September 5, 2025
IgG Antibodies
Posted inEmerging Science Genetic Engineering Immunology

Bacteria Engineered to Glycosylate Full-Length IgG: A Breakthrough in Antibody Production

A newly discovered single-subunit enzyme enables E. coli to glycosylate full-length IgG antibodies, paving the way for cost-effective biopharmaceutical production.
Posted by Aneknowledge September 1, 2025

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